Study1.5 (SCP Complex-LS)

Effects of Salmon Nasal Cartilage Extract Powder Standardized Undenatured Type ⅡCollagen and Proteoglycan on Knee Pain in Healthy Volunteers―A Single Center Randomized, Double—blind, Placebo—controlled Study：Re—analysis Results Focused on the Knee with Stronger Pain―

Yuji Kuriyama1)2), Masaki Narumi3), Hideharu Nakano3), Yasushi Yoshida2)
1) Anti-Aging Pro Corporation 2) Department of General Medicine, Juntendo University School of Medicine 3) Linise Co.,Ltd.

Keywords: Salmon nasal cartilage, Undenatured type Ⅱ colagen, Proteoglycan, Knee, Arthritis

Abstract

Background　A large number of studies have been conducted to investigate effects of undenatured type Ⅱ collagen and/or proteoglycan on arthritis. We reported the effect improving knee joint pain of the salmon nasal cartilage extract that contains both undenatured type Ⅱ collagen and proteoglycan（SCP complex-LS, Linise Co., Ltd.）in our article published in 2016. However, because the analyses in the article were performed regarding each of the right and left knees, only the left knee analysis results showed significant improvement. Objectives　This study aims to reevaluate effects of the salmon nasal cartilage extract on pain in both knees by conducting re︱analyses of the previous study data. Methods　A statistical analysis was performed using the scores of VAS pain for each of the knee with stronger pain and the contralateral knee, instead of the right knee and left knee. Results　Regarding the knee with stronger pain, the VAS score in a resting state and in going up and down stairs at Week 6 was significantly lower in the salmon nasal cartilage extract group than in the placebo group. Also, the VAS score for the contralateral knee in all three situations（in a resting state, in walking, and in going up and down stairs）at Week 6 was significantly lower in the salmon nasal cartilage extract group than in the placebo group. Conclusions　This re-analysis clearly showed that the 6 -week intake of salmon nasal cartilage extract containing undenatured type Ⅱ collagen and undenatured proteoglycan provides both knees with the benefit of reducing knee pain.

Japanese Pharmacology & Therapeutics. 2020; 48(11):2011-9.