Study1 (SCP Complex-LS)
Effects of Salmon Nasal Cartilage Extract Powder Standardized Undenatured Type II Collagen and Proteoglycan on Knee Pain in Healthy Volunteers: a single center randomized, double-blind, placebo-controlled study
Yuji Kuriyama1)2), Masaki Narumi3), Hideharu Nakano3), Yasushi Yoshida2)
1) Anti-Aging Pro Corporation 2) Department of General Medicine, Juntendo University School of Medicine 3) Linise Co.,Ltd.Keywords: knee pain, undenatured type II collagen, proteoglycan, immune tolerance
Abstract
Undenatured type II collagen and proteoglycan is nutritional supplement derived from cartilage. Previous studies have shown that undenatured type II collagen derived chicken sternum cartilage is effective in the treatment of knee osteoarthritis symptoms, and that proteoglycan suppress Th17 cells eliciting autoimmune arthritis. This study evaluated effects of salmon nasal cartilage extract powder (undenatured type II collagen: 40%, undenatured proteoglycan: 30%) on knee pain in healthy volunteers. The WOMAC score and the VAS score for knee pain of salmon nasal cartilage group (salmon nasal cartilage extract powder: 50mg/day) significantly decreased. The results suggest that the combination of undenatured type II collagen and proteoglycan is effective autoimmune arthritis involved knee pain.
J. New Rem. & Clin. 2016; 65: 1507-1521