Study2 (Red wine extract R5)

Effects of Grape Extract containing Resveratrol on Sustainable Flexibility of Blood Vessels and Lipid Metabolism in Healthy Volunteers: a single center, randomized, double-blind, placebo-controlled study

Yuji Kuriyama1)2), Yasushi Yoshida2), Sawako Hibino3)
1) Anti-Aging Pro Corporation 2) Department of General Medicine, Juntendo University School of Medicine 3) Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University

Keywords: resveratrol, french paradox, oligomeric proanthocyanidins, FMD, blood vessels, red wine

Abstract

Resveratrol attracts attention as one of important active ingredients of French paradox, and be frequently studied as possible ingredient for Sirtuin activation. One the latest study, the dosage is very important factor for Sirtuin activation. And it started to report that low-dose resveratrol supplementation improved several diseases related Sirtuin activation.
This study evaluated sustainable effects of grape extract (GE) containing low-dose resveratrol (20mg/day) and oligomeric proanthocyanidins (160mg/day) on flexibility of blood vessels and lipid metabolism in healthy volunteers for 12 weeks. The assessment was more than 12- hour later. On our results, the GE group was resulted in a about 30% (baseline: 5.1±2.3%, 12 week: 6.8±2.1%) increase in flow-mediated dilatation (FMD) compared with baseline. This average value changed to 6.8% exceeded the normal value (6.0%) in FMD. And it’s showed the significant difference in FMD compared with placebo group (P=0.043, independent t-test) and the down trend of blood pressure. The results suggest that the grape extract is effective sustainable flexibility of blood vessels. Regarding the lipid metabolism, the GE group protected the increasing of subcutaneous fat area slightly.

J. New Rem. & Clin. 2017; 66: 783-801